Organizers of the Sao Paulo tournament announced the entry of the 11-time Grand Slam winner on Tuesday.
Nadal hasn't played tennis since June, mainly because of tendinitis in his left knee. He was scheduled to play in an Abu Dhabi exhibition event last month, but a stomach virus forced him to withdraw and skip the Australian Open.
The Brazil Open starts on Feb. 11. He's also entered the Mexican Open in Acapulco from Feb. 25.
He won both tournaments the only previous time he entered them in 2005.