Hamlin has missed four races after sustaining a compression fracture of a vertebra in his lower back in a last-lap accident at California on March 24.
"Don't call it a comeback—LL cool J," Hamlin tweeted.
Joe Gibbs Racing said exact plans will be determined at the track. Hamlin could start the No. 11 Toyota, then give way to a relief driver.
"Welcome back Denny!" NASCAR tweeted.
Mark Martin took Hamlin's place in the No. 11 car at Martinsville, and Brian Vickers drove at Texas, Kansas and Richmond.