Usually so accurate, the Denver Broncos quarterback threw a pass he would like to have back.
Late in the first overtime, Manning tried to thread a throw to Brandon Stokley, only to have the pass intercepted by Corey Graham. A few plays after switching sides to start the second extra period, Justin Tucker hit a 47-yard field goal to help the Baltimore Ravens rally for a 38-35 win in an AFC divisional game on a bitterly cold Saturday.
Like that, Manning was once again left out in the cold. He's now 0-4 in games in which the temperature at kickoff is less than 40 degrees.
Manning even wore gloves on each hand to fight off the frigid conditions as temperatures that started out at 13 degrees dipped into single-digits. He heated up, too, only to cool off at the end.
This loss one may even sting a little more than any other for Manning. The Broncos were winning late in the game when Joe Flacco hit Jacoby Jones for a 70-yard TD with just 31 seconds left in regulation.
Soon after, the Ravens snapped the Broncos' 11-game winning streak and ended Manning's impressive comeback from four neck operations that kept him out all of last season.
To add insult, it was here, in this stadium, where Manning's predecessor, Tim Tebow, connected with Demaryius Thomas for a game-winning TD in overtime against Pittsburgh in the playoffs last season.
After Tucker's kick, Manning began a slow walk to the other side of the field, where he worked his way into a circle of reporters that surrounded Baltimore linebacker Ray Lewis. Once inside, he gave Lewis a quick hug before trudging off the field.
Lewis will play another week, his retirement party on hold.
Manning, well, his season is done. He made a costly throw at a costly time.
"He's one of the greatest quarterbacks of all time and for us to come in here and confuse him the way we did, and make the plays we did?" Lewis said. "We gave up two big special teams touchdowns, but the bottom line is, but we kept fighting."
Manning finished 28 of 43 for 290 yards and three scores. But more memorable than those touchdowns will be his two picks.
Sure, one was tipped—that happens. But the other? It's a throw that maybe he's gotten away with at times in his 15-year career. Just not this time.